Endocrine Abstracts

Neurons in the CA1 region of the rodent hippocampus express high levels of the nuclear mineralocorticoid (MR) and glucocorticoid receptors (GR). The MR affinity is such that low levels of corticosterone -as seen under rest- already substantially activate this receptor. Hence, for many years the GR was considered to be the main mediator of the stress response. This receptor causes (among other things) a delayed enhanced influx of calcium into CA1 neurons, an enhancement of sero...